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Xi Shu; Happy Tree
Taxonomic ClassificationCornaceae family
Camptotheca acuminata (Nyssaceae) is a Chinese tree that produces the pentacyclic quinolines camptothecin and 10-hydroxycamptothecin through the monoterpene indole alkaloid pathway. Camptothecin inhibits DNA topoisomerase I and is very effective against cancer cells in culture. However, severe side effects limit camptothecin's usefulness in patients. Currently, two semi-synthetic derivatives of camptothecin, topotecan and irinotecan, which retain anti-cancer activity but with less severe side effects, are used to treat a variety of cancers, particularly those of colorectal and gynecological origin. Additional semi-synthetic derivatives of camptothecin are being developed, but they too begin with the natural product as the starting point.
|Chemical Structure: Camptothecin||Clinical Trials||Major Metabolites|
|Enzyme Name||EC No||Genbank Accession||GI No|
aThe Total Entries column is the sum of the entries from the dbEST, dbGSS, dbPLN, and dbHTG columns. Data retrieved from NCBI on May 14 2010.