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Taxonomic ClassificationPlantaginaceae family
Digitalis purpurea had been used for many years as a folk medicine, but was reported to contain a cardio-active compound in 1785. Two of the active components, digitoxin and digoxin, inhibit sodium-potassium ATPase. Digoxin (Lanoxin, Digitek, and Lanoxicaps) is used to treat cardiac arrhythmias, atrial fibrillation and atrial flutter. Digitoxin and digoxin are glycosylated triterpenes, often referred to as cardiac glycosides. Digoxigenin, a steroid, is used as a probe to detect DNA and can be readily covalently attached to nucleotides.
|Chemical Structure: Digitoxin||Clinical Trials||Major Metabolites|
|Enzyme Name||EC No||Genbank Accession||GI No|
|3-beta hydroxysteroid dehydrogenase||220.127.116.11||AAV68716.1||55978465|
|Progesterone 5 beta-reductase||N/A||ACZ66261.1||270269274|
aThe Total Entries column is the sum of the entries from the dbEST, dbGSS, dbPLN, and dbHTG columns. Data retrieved from NCBI on May 14 2010.